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After spending the night with Tatiana, Monroe meets Brendan,a middle-aged family man whose tumour is giving him epileptic fits. Supported by his teen-aged daughter Phoebe,Brendan believes that the fits bring him closer to God though he eventually agrees to surgery,to Phoebe's dismay. However Springer has his doubts as to the operation's success. Jenny has two very different patients,James,an orphan with Downs' Syndrome and cocky ladies' man Alex though they hit it off through their mutual love of computer games. Jenny and Laurence do not thank Monroe for gloating over the collapse of their affair but at least they give it another go whereas all he has is his poker club,having been accused by Anna of finding a new partner too soon and by Tatiana of using her to hit out at his wife.
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Sally Fortune,one of Monroe's team,collapses during an operation and is revealed to have a life-threatening aneurysm requiring immediate surgery. It is successful and even brings Monroe closer to Springer. Nick believes his father should fight harder to save his marriage, which leads to their also becoming closer. Mullery rejoices at sally's recovery whilst Jenny and Lawrence agree to carry on their relationship.
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Jenny and Lawrence now have a baby,Louis,and Jenny returns to work from maternity leave to find several changes - which do not please Monroe. New head of clinic Gillespie disapproves of mavericks whilst Monroe sees nurse specialist Lizzie,appointed to give patient support,as taking on his role. At home Monroe invites ex-wife Anna and her new partner,vet Dave,for dinner where son Nick drops a bombshell by saying that he intends to marry his girlfriend Donna shortly. Jenny feels at home after operating on an elderly patient but relations with Lawrence are strained. Monroe defies Gillespie by performing a dangerous operation successfully,after which he is told that only one of his trainees,Kitty Wilson or Springer,can be promoted to registrar.
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Whilst Lizzie attempts to build bridges Monroe is still resentful of Gillespie's interference - ultimately promoting Springer over Kitty Wilson. The surgeons are kept busy with a variety of cases,including Shelley Maxwell,a young girl whose brain shunt,fitted as a baby,is starting to malfunction but worries that,once it is fixed,her estranged parents will have no reason to unite,Lizzie intervening to help. Lynn Monkford believes she will die of cancer within a year,requiring Monroe to perform a delicate operation to reduce her tumour so that she may have some quality of life and Graham Birdwell needs a double heart by-pass helped by his disabled brother. Mullery comes to the rescue of Sarah Witney when she wavers over an emergency admission with a nail in his chest but Lawrence and Jenny are rapidly drifting apart. She suggests counselling but instead he seeks comfort with Sarah.
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Following his failure to save Lynn Mountford Monroe is doubting his capabilities,even taking advice from Gillespie. He rallies to the occasion when 25-year old,mother-dominated Alex Schofield has a benign tumour in his spine but stops halfway through the operation. However,having successfully removed a knife from a rugby fan's head in an emergency operation he regains his confidence and removes Alex's tumour. Jenny meanwhile successfully races against time to save a little Pakistani girl and she and Lawrence go for counselling though Sarah has had to stop Lawrence from telling Jenny about their fling. Sarah agrees to go on a date with Springer,who is allowing his new status as registrar to go to his head,but she makes sure they end up at Monroe's cards school.
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His confidence restored and aware that Anna is happy with her new man Monroe goes on a date with Lizzie though it is inadvertently interrupted by Nick. After being caught shop-lifting and lashing out Sally Indale's violent personality is attributed to an aneurysm in her temporal lobe. Monroe successfully operates but,on coming to,Sally is shown to be naturally aggressive whilst Sarah,having persuaded Max Portas,an amateur footballer with myocarditis,that it is in his interests to have an operation,has cause for regret. Sarah is still dating Springer,who is unaware of her fling with Lawrence. Lawrence,feeling guilty and unable to sustain his relationship with Jenny,moves in with Monroe.
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Monroe is amused when Springer gets a lawyer's letter following his inability to distinguish between a tumour and an abcess. Monroe himself is preparing to operate on straight-talking Bridget Addy to cure her epilepsy. She is unhappy when he tells her that she will only have a local anaesthetic as he removes part of her brain so he can check her speech so Lizzie persuades Neil,Bridget's ex-husband,to be give - reluctant - support,though he does not stay around after the operation. Jenny deals with teen-aged Grace Bushnall,who has been promised a heart transplant for some years and is now reluctant to have the operation though Jenny persuades her and again Sarah proves her worth. Gillespie also finds Mullery ever more impressive as they operate together on a man in need of an aortal graft. Lawrence decides to go back to Jenny whilst Monroe decides that he and Lizzie are never destined to be more than friends after he has sex with Anna.
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Monroe introduces medical student Jacob Namobu to the ward as Jenny,having learned of Lawrence's infidelity from Monroe,tells him they should split up and a guilty Sarah tenders her resignation. On the eve of his wedding Nick tells his father he has doubts about going through with it but a family party is interrupted following a traffic pile-up and the need for all surgical staff to operate on the victims. When one dies Jacob has doubts about the job but is counselled by Monroe. Jenny refuses to accept Sarah's resignation and it is Lawrence who moves on whilst Springer actually admits his feelings for Sarah. Next day Monroe finds that Anna has talked Nick into getting married and they both attend his wedding.
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